Automatic Eight Head Closed Ampoule Filling & Sealing Machine
Maximum Efficiency for Closed Glass Solutions
The Harsiddh Automatic Eight Head Closed Ampoule Filling & Sealing Machine (Model HFS-8 C) is the flagship high-speed solution for manufacturers requiring the highest sterile standards. Designed for the pharmaceutical, vaccine, and chemical industries, this machine processes 1ml to 10ml Closed-mouth ampoules with extreme precision. Its eight-head configuration allows for a massive production output, reaching up to 225 to 250 ampoules per minute (depending on size).
Operational Precision & Process Flow
Built on the proven Incline/Slant Drive Principle, the HFS-8 C ensures stable transportation of ampoules, effectively managing variations in neck dimensions and glass thickness.
Sequence of Operation:
- Rectangular Feeding: Pre-sterilized closed ampoules are loaded into the slant hopper and indexed via a star wheel and eccentric rack synchronization.
- Drawing/Opening Station: Eight specialized heating nozzles precisely open the closed neck of the ampoules using a mixture of LPG and Oxygen.
- Sterile Filling: After pre-nitrogen purging, eight high-precision volumetric piston pumps discharge the liquid dose simultaneously with high repeatability.
- Sealing & Tip Disposal: Post-nitrogen purging is followed by pre-heating and final sealing. Integrated clippers pick up waste glass tips and deposit them into the SS collector.
- Automated Discharge: Duly filled and sealed ampoules are collected via a “sleepy tray” or vertical collection unit, ensuring zero manual contact.
Advanced Control Options
- Variable Speed Control: Equipped with a Delta Variable Frequency Drive (VFD) for seamless production speed regulation.
- Digital Integration (Optional): Available with a PLC and Touch Screen HMI for centralized digital monitoring.
- Flexible Filling Systems: Can be customized with Servo-based filling or Peristaltic pumps for handling highly sensitive or high-value biological liquids.
Technical Specification
| Specification | Details (HFS-8 C High Speed) |
|---|---|
| Number of Heads | Eight (Opening, Filling & Sealing) |
| Ampoule Size Range | 1ml to 10ml Closed / D Type Glass |
| Production Output | 80 to 250 Ampoules / Minute |
| Filling Capacity | 0.5ml to 10ml in Single Dose |
| Filling Accuracy | Up to +/- 0.5% |
| Gases Required | LPG & Oxygen (for Opening & Sealing) |
| Power Requirements | 1.5 H.P., 380V/220V Options |
| Machine Dimensions | Approx. 2430mm (L) x 1200mm (W) x 1000mm (H) |
Frequently Asked Questions
What is the production capacity of this Eight Head model?
The Eight Head configuration is engineered for high-volume pharmaceutical manufacturing. Depending on the ampoule size (typically 1ml to 10ml) and the characteristics of the liquid, this machine can achieve a consistent output of 150 to 200 ampoules per minute. This makes it an ideal choice for large-scale injectable production lines requiring maximum efficiency.
How does the machine open the pre-sealed ampoules?
The machine features an integrated Opening Station before the filling zone. As the closed ampoules move along the "Walking Beam" transport system, a precision flame burner softens the glass tip, which is then mechanically removed or "clipped" to create a clean opening. This happens synchronized with the filling cycle to ensure the interior is exposed to the cleanroom environment for the shortest time possible.
How does the machine ensure dosing accuracy and product stability?
To meet strict pharmaceutical standards, the machine uses eight high-precision SS 316L volumetric syringes or peristaltic pumps, providing a filling accuracy of ±1%. To protect oxygen-sensitive drugs, the machine includes:
Pre-Gassing: Nitrogen flushing to displace oxygen before filling.
Post-Gassing: Nitrogen flushing after filling to ensure a stable shelf life.
No Ampoule – No Fill: A sensor system that prevents liquid wastage if an ampoule is missing from the line.
What are the key cGMP and safety features of the machine?
As a cGMP-compliant unit, the Harsiddh Eight Head Closed Ampoule machine is built for sterile environments:
Materials: All contact parts are SS 316L, while the main frame and non-contact parts are SS 304 stainless steel.
Laminar Air Flow (LAF): The slim, linear design is optimized for installation under LAF units to maintain a Class 100 sterile zone.
Safety Enclosure: It comes with a full acrylic safety cabinet and door interlocks that automatically stop the machine if opened during operation.
PLC Control: A centralized PLC with a Touchscreen HMI allows for precise adjustment of all parameters, including burner flame intensity and conveyor speed.
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