Automatic Four Head Closed Ampoule Filling & Sealing Machine
High-Speed Processing for Closed Glass Solutions
The Harsiddh Automatic Four Head Closed Ampoule Filling & Sealing Machine (Model HFS-4 C) is a new-generation solution for pharmaceutical, chemical, and cosmetic industries. While standard machines handle open ampoules, the HFS-4 C is built for the high-precision processing of Closed/D-Type glass ampoules. This model combines four independent heads to open, fill, and seal simultaneously, delivering a high-output capacity of 60 to 95 ampoules per minute.
Operational Precision & Sequential Process
Utilizing the Incline/Slant Drive Principle, the machine ensures stable handling even with variations in ampoule neck dimensions or glass thickness.
Sequence of Operation:
- Rectangular Feeding: Replaces conventional feeding methods to reduce glass-to-glass contact and prevent breakage.
- Opening Station: Specialized heating nozzles use an LPG/Oxygen mixture to precisely open the closed mouth of the ampoules.
- Sterile Filling: After pre-nitrogen flushing, four precision volumetric piston pumps discharge the liquid (0.5ml to 5ml) with high accuracy.
- Sealing & Tip Disposal: Ampoules pass through a pre-heating station and are then hermetically sealed. An integrated plunger picks up waste glass tips and drops them into a dedicated SS collector.
- Automated Discharge: Finished ampoules are diverted via a “sleepy tray” into the collection unit without any human touch.
Efficiency for Global Standards
The HFS-4 C is the ideal choice for facilities requiring the highest sterile and hygienic standards, particularly for vaccines and human consumption liquids. With its four-head configuration, it offers the perfect balance of industrial speed and compact footprint, significantly reducing changeover time between different batch sizes.
Technical Specification
| Model No. | HFS-4 C |
|---|---|
| Number of Heads | Four (Opening, Filling & Sealing) |
| Ampoule Size Range | 1ml to 5ml (10ml available in 2’s) |
| Production Output | 60 to 95 Ampoules / Minute |
| Filling Capacity | 0.5ml to 5ml in Single Dose |
| Filling Accuracy | +/- 1% |
| Gases Required | LPG & Oxygen (for Opening & Sealing) |
| Power Requirements | 1 H.P., 380V/220V Options |
| Machine Dimensions | 1250mm (L) x 1200mm (W) x 1300mm (H) |
| Net Weight | Approx. 315 Kgs |
Frequently Asked Questions
What is the production capacity of the Four Head Closed Ampoule model?
The Four Head configuration is a medium-to-high speed linear machine. Depending on the ampoule size (typically 1ml to 10ml) and the viscosity of the liquid, this machine can achieve a consistent output of 70 to 100 ampoules per minute. It is an ideal solution for pharmaceutical companies looking for high-quality aseptic filling with a compact cleanroom footprint.
How does the machine open the ampoules before filling?
The machine features an integrated Ampoule Opening Station located before the filling zone. As the closed ampoules move along the "Walking Beam" transport system, a precision flame burner softens the pre-sealed glass tip, which is then mechanically clipped or removed. This ensures the ampoule is only open for the minimum time required for filling and gassing.
How does the machine ensure dosing accuracy and product stability?
To meet strict pharmaceutical standards, the machine uses four high-precision SS 316L volumetric syringes or peristaltic pumps, providing a filling accuracy of ±1%. To protect oxygen-sensitive injectable drugs, the machine includes:
Pre-Gassing: Nitrogen flushing to displace oxygen before filling.
Post-Gassing: Nitrogen flushing after filling to ensure a stable shelf life.
No Ampoule – No Fill: A sensor system that prevents liquid wastage if an ampoule is missing from the line.
What are the key cGMP and safety features of the machine?
As a cGMP-compliant unit, the Harsiddh Four Head Closed Ampoule machine is built for sterile environments:
Materials: All contact parts are SS 316L, while the main frame and non-contact parts are SS 304 stainless steel.
Laminar Air Flow (LAF) Ready: The slim, linear design is optimized for installation under LAF units to maintain a Class 100 sterile zone.
Safety Enclosure: It comes with a full acrylic safety cabinet and door interlocks that automatically stop the machine if opened during operation.
PLC Control: A centralized PLC with a Touchscreen HMI allows for precise adjustment of all parameters, including burner flame intensity and conveyor speed.
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