Automatic Two Head Closed Ampoule Filling & Sealing Machine
High-Efficiency Processing for Closed Ampoules
The Harsiddh Automatic Two Head Closed Ampoule Filling & Sealing Machine (Model HFS-4 C) is a robust and highly functional solution designed for the aseptic preparation of Closed/D-Type glass ampoules. Combining opening, volumetric filling, and hermetic sealing into one continuous automated process, this machine is ideal for medium-scale production in the Pharmaceutical, Cosmetic, and Chemical sectors.
Operational Precision & Process Flow
This machine is built for reliability, using a volumetric piston pump mechanism to ensure consistent dosing accuracy for liquids ranging from 0.5ml up to 5ml (with models available up to 25ml).
Sequence of Operation:
- Ampoule Opening: Multiple LPG/Oxygen nozzles precisely open the pre-sealed closed ampoules as they enter the station.
- Nitrogen Purging: Pre-filling gassing removes atmospheric oxygen to ensure a stable environment for the medicament.
- Two-Head Volumetric Filling: Dual precision heads discharge the liquid dose simultaneously, doubling production efficiency compared to single-head models.
- Heating & Sealing: After post-filling nitrogen purging, ampoules pass through the pre-heating station before the final hermetic sealing.
- Automated Collection: Finished ampoules are diverted into a vertical tray collection unit without human intervention, ensuring zero contamination.
Why Choose the Two-Head Configuration?
The two-head model provides a significant boost in productivity, achieving outputs of 60 to 90 ampoules per minute depending on size. It offers the perfect balance between compact footprint and industrial-grade throughput, making it a reliable asset for sterile injection preparation where precision and speed are paramount.
Technical Specification
| Model No. | HFS-4 C |
|---|---|
| Number of Heads | Two (Filling & Sealing) |
| Ampoule Type | 1ml to 5ml Closed / D Type Glass |
| Production Output | 60 to 90 Ampoules / Minute |
| Filling Capacity | 0.5ml to 5ml (Single Dose) |
| Gases Required | LPG & Oxygen (for Opening & Sealing) |
| Nitrogen Purging | Available (Pre & Post) |
| Power Requirements | 1 H.P., 3-Phase or 1-Phase Options |
| Machine Dimensions | 1250mm (L) x 800mm (W) x 1000mm (H) |
Frequently Asked Questions
How does the machine open the pre-sealed glass tips?
The machine features an integrated Ampoule Opening Station located before the filling zone. As the ampoules move along the transport system, a precision flame burner softens the glass tip, which is then mechanically clipped or removed. This process is synchronized so the ampoule is only open for a few seconds during the nitrogen flushing and filling stages, minimizing any exposure to the cleanroom environment.
What is the production capacity of the Two Head Closed Ampoule model?
The Two Head configuration is an ideal solution for pilot plants, clinical trials, and small-to-medium scale production. Depending on the ampoule size (typically 1ml to 10ml) and the viscosity of the liquid, this machine can achieve a consistent output of 30 to 50 ampoules per minute (approximately 1,800 to 3,000 per hour). It offers professional-grade automation with a compact footprint.
How does the machine ensure dosing accuracy and prevent wastage?
To meet strict pharmaceutical standards, the machine is equipped with:
High-Precision Filling: Two volumetric SS 316L syringes or peristaltic pumps provide a filling accuracy of ±1%.
No Ampoule – No Fill: A sophisticated sensor system ensures the pumps only activate when an ampoule is present, preventing the loss of expensive medicinal liquids.
Nitrogen Gassing: Integrated pre- and post-filling nitrogen flushing stations displace oxygen to ensure the long-term stability and shelf life of the product.
What are the key cGMP and safety features of this machine?
As a cGMP-compliant unit, the Harsiddh Two Head Closed Ampoule machine is built for the most rigorous sterile environments:
Materials: All liquid contact parts are made of SS 316L, while the exterior frame is polished SS 304 stainless steel.
Laminar Air Flow (LAF) Ready: The slim, linear design is optimized for installation under LAF units to maintain a Class 100 sterile zone.
Advanced Control: Managed by a centralized PLC with a Touchscreen HMI, allowing for precise digital adjustment of burner flames, conveyor speed, and production monitoring.
Safety Enclosure: Features a full acrylic safety cabinet with interlock sensors that automatically stop the machine if the doors are opened during operation.
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