Automatic Six Head Closed Ampoule Filling & Sealing Machine
High-Volume Aseptic Processing
The Harsiddh Automatic Six Head Closed Ampoule Filling & Sealing Machine (Model HFS-6 C) is a high-performance solution also known as “Ampoule Drawing, Filling, and Closing Equipment.” It is specifically designed for Pharmaceutical, Chemical, and Cosmetic manufacturers who require the highest levels of sterility provided by closed-neck ampoules. This high-speed machine handles volumes from 0.5ml to 10ml with unmatched precision and volumetric accuracy.
Operational Precision & Process Flow
The machine utilizes an indexing cam mechanism to transfer ampoules through several critical stages without human intervention, ensuring zero contamination.
Sequence of Operation:
- Sterile Loading: Pre-sterilized D-Type ampoules are loaded into the hopper and moved via a cassette magazine onto an eccentric rack.
- Opening: Six specialized nozzles use an LPG/Oxygen gaseous mixture to precisely heat and open the closed-neck ampoules.
- Filling & Purging: After pre-nitrogen purging, six precision volumetric piston pumps discharge the liquid. Post-nitrogen purging follows to protect the product.
- Sealing: Ampoules are pre-heated and then hermetically sealed as they rotate smoothly at the sealing station.
- Collection: Finished ampoules are automatically diverted into a vertical tray collection unit.
Technical Specification
| Model No. | HFS-6 C (High Speed) |
|---|---|
| Number of Heads | Six (Opening, Filling & Sealing) |
| Ampoule Size Range | 1ml to 10ml Closed / D Type Glass |
| Output / Minute | 80 to 150 Ampoules (Depending on size) |
| Filling Capacity | 0.5ml to 10ml (Single Dose) |
| Filling Type | Volumetric Piston Pump |
| Gases Required | LPG & Oxygen (for Opening & Sealing) |
| Contact Parts | Stainless Steel AISI 316L |
| Machine Dimensions | 2380mm (L) x 1200mm (W) x 1000mm (H) |
| Net Weight | Approx. 990 Kgs |
Frequently Asked Questions
How does the machine open the pre-sealed glass tips?
The machine features an integrated Ampoule Opening Station located before the filling zone. As the ampoules move along the transport system, a precision flame burner softens the glass tip, which is then mechanically clipped or removed. This process is synchronized so the ampoule is only open for a few seconds during the nitrogen flushing and filling stages, minimizing environmental exposure.
What is the production capacity of the Six Head Closed Ampoule model?
The Six Head configuration is engineered for medium-to-high speed pharmaceutical manufacturing. Depending on the ampoule size (typically 1ml to 10ml) and the viscosity of the liquid, this machine can achieve a consistent output of 100 to 150 ampoules per minute. It offers a perfect balance of high throughput and a compact cleanroom footprint.
How does the machine ensure dosing accuracy and prevent wastage?
To meet strict pharmaceutical standards, the machine is equipped with:
High-Precision Filling: Six volumetric SS 316L syringes or peristaltic pumps provide a filling accuracy of ±1%.
No Ampoule – No Fill: A sophisticated sensor system ensures the pumps only activate when an ampoule is present, preventing the loss of expensive medicinal liquids.
Nitrogen Gassing: Includes pre- and post-filling nitrogen flushing to displace oxygen and ensure the long-term stability of the product.
What are the key cGMP and safety features of this machine?
As a cGMP-compliant unit, the Harsiddh Six Head Closed Ampoule machine is built for the most rigorous sterile environments:
Materials: All liquid contact parts are made of SS 316L, while the exterior frame is polished SS 304 stainless steel.
Laminar Air Flow (LAF) Ready: The slim, linear design is optimized for installation under LAF units to maintain a Class 100 sterile zone.
Advanced Control: Managed by a centralized PLC with a Touchscreen HMI, allowing for precise digital adjustment of burner flames, conveyor speed, and production monitoring.
Safety Enclosure: Features a full acrylic safety cabinet with interlock sensors that automatically stop the machine if the doors are opened during operation.
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