Automatic Injectable Vial Dry Powder Filling & Stoppering Machine (Single Wheel / Head) (Volumetric)
Precision Filling for Sterile Injectables
The Harsiddh Automatic Injectable Dry Powder Filling & Stoppering Machine is a compact, high-performance monoblock designed for the stringent requirements of the pharmaceutical industry. This system specializes in handling 5ml to 30ml glass vials, providing a single-dose capacity of 50mg to 1.5 grams. Its single-wheel design is engineered for maximum reliability, ensuring that every vial is filled with uniform density and securely stoppered under controlled humidity conditions.
Reliable Operational Workflow
The machine provides a continuous, automated process from vial entry to hermetic sealing.
Sequence of Operation:
- In-feed: Vials are fed automatically via a rotary turn table onto the SS slat conveyor.
- Volumetric Filling: A vacuum-suction powder wheel pulls the calibrated dose into its ports. Excess powder is removed by a doctor blade before being discharged into the vial.
- Validation: Sensors confirm vial alignment; if no vial is detected, the vacuum/piston cycle for that port is bypassed to prevent powder loss.
- Stoppering: Filled vials move to the vibratory station where rubber stoppers (20mm) are accurately picked and pressed into the vial necks.
- Discharge: Sealed vials are released for the next stage of aluminum capping or inspection.
Technical Specification
| Specification | Details (HPF-120 Series) |
|---|---|
| Production Output | 40 to 100 Vials Per Minute |
| Vial Size Range | 5ml to 30ml Glass Vials (Dia. 22mm to 38mm) |
| Filling Capacity | 50mg to 1.5g (Single Dose); Up to 6g (Multi-Dose) |
| Filling Accuracy | ± 1% (Subject to Bulk Density & Humidity) |
| Rubber Stopper Size | 20mm (Standard) |
| Contact Parts | Stainless Steel AISI 316L |
| Main Drive | Imported Gear Motor with VFD |
| Sterilization | All contact parts are Autoclavable |
Frequently Asked Questions
What is the production capacity of the Single Wheel model?
The Single Wheel (or Single Head) configuration is designed for medium-scale production and pilot plants. Depending on the vial size and the flow characteristics of the powder, it typically achieves an output of 60 to 120 vials per minute. It offers a more compact footprint and lower utility consumption compared to double-wheel high-speed models.
Can the machine handle different vial sizes and powder volumes?
Yes. The Harsiddh Single Wheel model is highly flexible and can process glass vials ranging from 2ml to 100ml.
Volume Adjustment: The fill weight can be adjusted by changing the piston depth within the dosing wheel or by swapping the wheel for a different cavity size.
Vial Diameter: The "Walking Beam" or star-wheel transport system features quick-change parts to accommodate various vial diameters and heights.
How is the rubber stoppering process synchronized with the filling?
Immediately after the powder is filled, the vials move to the Integrated Stoppering Station. Rubber stoppers are sorted via a sterile Vibratory Bowl Feeder and delivered to a pick-up point. The machine uses a mechanical "Pick & Place" system to insert the stoppers into the vial necks. This ensures the powder is sealed and protected from humidity and environmental contaminants within seconds of being filled.
What are the key cGMP and maintenance features of this machine?
As a cGMP-compliant unit, it is built for the highest pharmaceutical hygiene standards:
Material Integrity: All powder contact parts are SS 316L, and the main structure is SS 304 stainless steel.
Safety Sensors: Features "No Vial – No Fill" and "No Vial – No Stopper" interlocks to prevent medicinal wastage and ensure batch quality.
Laminar Air Flow (LAF) Compatibility: The slim, linear design is optimized for installation under a Class 100 LAF unit to maintain a sterile atmosphere.
Easy Cleaning: The dosing wheel and hopper are designed for rapid dismantling to facilitate thorough cleaning between different product batches.
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