Automatic Injectable Liquid Vial Filling & Stoppering Machine
High-Precision Vial Processing for Sterile Injectables
The Harsiddh Automatic Injectable Liquid Vial Filling & Stoppering Machine (HLVF Series) is a state-of-the-art solution designed for the pharmaceutical, R&D, and chemical industries. This monoblock equipment seamlessly receives sterile vials and subjects them to high-accuracy liquid dosing followed by immediate vibratory rubber stoppering to maintain maximum aseptic integrity.
Operational Precision & Scalable Production
Built with a linear left-to-right on-line mechanism, this machine utilizes a star wheel positioning system to ensure vials are perfectly aligned under the nozzles during the volumetric filling process.
Sequence of Operation:
- Feeding: Vials are fed via an in-feed turn table (un-scrambler) onto the conveyor.
- Nitrogen Purging: Pre-filling gassing removes oxygen from the vial interior.
- Volumetric Filling: Precision syringes and nozzles discharge the liquid dose with ±1% accuracy.
- Stoppering: Filled vials move to the vibratory system where rubber stoppers are applied.
- Discharge: Finished vials are collected via an out-feed turn table (scrambler).
Technical Specification
| Specification | HLVF – 60 (2 Head) | HLVF – 100 (4 Head) | HLVF – 150 (6 Head) |
|---|---|---|---|
| Output / Minute | 30 to 50 Vials | 50 to 100 Vials | 100 to 150 Vials |
| Vial Size Range | 2ml to 100ml | 2ml to 100ml | 2ml to 100ml |
| Filling Accuracy | ± 1% | ± 1% | ± 1% |
| Filling Type | Volumetric Piston Pump | Volumetric Piston Pump | Volumetric Piston Pump |
| Stopper Sizes | 13, 20, 28, 32mm | 13, 20, 28, 32mm | 13, 20, 28, 32mm |
| Contact Parts | SS 316L | SS 316L | SS 316L |
| Power Requirements | 1.0 H.P. Main | 1.0 H.P. Main | 1.0 H.P. Main |
Frequently Asked Questions
How does the machine ensure high dosing accuracy for expensive injectables?
To meet strict pharmaceutical standards, the machine utilizes high-precision SS 316L volumetric syringes or optional peristaltic pumps. These systems provide a filling accuracy of ±1%. It also features a "No Vial – No Fill" sensor system, which ensures that the filling pump only activates when a vial is correctly positioned, preventing medicinal wastage and maintaining a clean conveyor environment.
How are the rubber stoppers handled and inserted into the vials?
After the filling process, the vials move to the stoppering station. Rubber stoppers are fed through a Vibratory Bowl Feeder onto a chute. The machine uses a "Pick & Place" or "Vacuum-assisted" mechanism to partially or fully insert the stoppers into the vial necks. This process is synchronized with the vial movement to ensure center-aligned placement, which is critical for maintaining sterility before the final crimping stage.
Can this machine handle oxygen-sensitive liquid formulations?
Yes. To protect sensitive injectable drugs from oxidation, the machine is equipped with integrated Pre-gassing and Post-gassing units. These units flush the vials with Nitrogen (or other inert gases) before and after the filling process. This displace the oxygen within the vial headspace, ensuring the chemical stability and extended shelf life of the medication.
What are the key cGMP and safety features of this model?
As a cGMP-compliant unit, the Harsiddh Vial Filling & Stoppering machine is built for the most rigorous sterile environments:
Material Integrity: All liquid contact parts are made of SS 316L, while the exterior structure is SS 304 stainless steel.
Laminar Air Flow (LAF) Integration: The slim, linear design is specifically optimized for installation under LAF units to maintain a Class 100 sterile zone.
Safety Enclosure: It features a full acrylic safety cabinet with interlock sensors that automatically stop the machine if the doors are opened during operation.
Centralized Control: A user-friendly PLC with a Touchscreen HMI allows for real-time monitoring of production speeds, "No Vial-No Stopper" alerts, and batch data logging.
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