Automatic Highspeed Vertical Ampoule Filling & Sealing Machine
High-Efficiency Vertical Sterile Processing
The Harsiddh High Speed Eight Head Vertical Ampoule Filling & Sealing Machine (Model HFS-300V) represents the pinnacle of injectable packaging technology. Unlike horizontal models, the vertical transport mechanism ensures that ampoules are held securely in an upright position throughout the process, significantly reducing jerk and glass-to-glass contact. This machine is ideal for processing varied ampoule sizes from 1ml to 10ml with a filling capacity ranging from 0.5ml to 10ml in a single dose.
Operational Precision & Sequential Process
The machine is built on a heavy-duty SS square pipe frame with large openings at the bottom for absolute cleaning and maintenance accessibility.
Sequence of Operation:
- In-feed: Ampoules are fed via an SS conveyor directly from a sterilizing tunnel and transferred to a segment wheel.
- Vertical Transfer: A moving rack carries the ampoules in a vertical position through the various processing stations one by one.
- Filling Station: Eight precision volumetric piston pumps dispense the liquid with high accuracy, synchronized via a mechanical cam drive.
- Sealing Station: Ampoules are rotated by a separate drive unit at the sealing station. A mixture of LPG and Oxygen is used to create a defect-free, uniform seal, with a pre-heating station provided for thick glass ampoules.
- Discharge: Successfully filled and sealed ampoules are automatically diverted into the collection tray.
Advanced Control & Settings
- Variable Speed: Tremendously variable speed control to achieve optimum production levels based on ampoule size.
- Centralized Volume Adjustment: Manual infinitely variable adjustment of syringes for dosing volume by a central setting rod, with individual fine-tuning for each syringe.
- Flow Monitoring: Equipped with acrylic body gas flow meters for easy flame setting and gas/oxygen mixture monitoring.
Technical Specification
| Model No. | HFS-300V (High Speed On-Line Model) |
|---|---|
| Number of Heads | Eight (Vertical Filling & Sealing) |
| Production Output | 80 to 280 Ampoules / Minute (Up to 17,000/Hr) |
| Ampoule Size Range | 1ml to 10ml Open Mouth Glass Ampoules |
| Filling Accuracy | +/- 1% |
| Filling Type | Volumetric Piston Pump |
| Power Requirements | 2.0 H.P., 3-Phase or 1-Phase Options |
| Machine Dimensions | 2950mm (L) x 1000mm (W) x 1200mm (H) |
| Net Weight | Approx. 1550 Kgs |
Frequently Asked Questions
What is the production capacity of this Highspeed model?
The Harsiddh Highspeed Vertical model is engineered for mass production. Depending on the number of filling heads (available in 8, 10, or 12-head configurations) and the ampoule size, this machine can achieve a massive output ranging from 200 to 400 ampoules per minute. This makes it the premier choice for large pharmaceutical plants requiring 24/7 high-volume injectable production.
How does the machine maintain dosing accuracy at such high speeds?
Precision is maintained through a synchronized Servo-Driven or Mechanical Cam-Operated Filling System. Using high-precision SS 316L volumetric syringes, the machine achieves a filling accuracy of ±1%. Even at maximum speed, the "No Ampoule – No Fill" electronic sensor ensures that no medicine is wasted if a gap is detected in the vertical carrier.
How is the sealing quality controlled to prevent contamination?
The machine utilizes a multi-station heating process followed by the "Draw-off Sealing" method.
Pre-Heating: Gradually warms the glass to prevent thermal shock.
Sealing: Precision Oxygen-LPG burners melt the glass while a mechanical gripper pulls away the waste tip.
Gas Flushing: Integrated pre- and post-nitrogen flushing stations displace oxygen, ensuring the stability and extended shelf life of sensitive injectable drugs.
What are the key cGMP and maintenance features of this machine?
As a cGMP-compliant unit, the machine is built for longevity and sterile integrity:
Materials: All contact parts are SS 316L, and the exterior is SS 304 stainless steel with a high-polish finish.
Vertical Slim Design: The narrow footprint is specifically optimized for installation under Laminar Air Flow (LAF) units to maintain a Class 100 sterile environment.
Advanced Automation: Controlled via a centralized PLC with a Large Touchscreen HMI, allowing operators to monitor real-time production statistics, burner pressures, and diagnostic alerts.
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