Automatic Biological Indicator Filling & Sealing Machine
Exclusive AUTOMATIC BIOLOGICAL INDICATOR FILLING & SEALING MACHINE introduced by Harsiddh including onion skin tube (OST) filling machine & glass tube filling machine. The contact parts of this filler sealer are made of AISI 316L grade stainless steel with a customized single motor that complies with all different major unit drives. This biological indicator filling machine possesses both post & pre nitrogen flushing units and also operates the mechanism of nitrogen-flushing. Another benefit of this filling machine is the need of minimum ampoule/tubes changes. Our CE certified biological indicator filling machines also have an active pre-heating unit suitable for thick glass ampoules.
Biological Indicator Filling Machine
This range of filler and sealer machine includes onion skin tube filler sealer machine & crushable glass tube filler sealer machine has the capacity to fill and seal glass tubes up to the capacity of 10ml. With the help of this glass tube filling and sealing machine has a capacity of filling material from 0.1 – 10 ml in single doses. This biological indicator filling machine has a production capacity from 10-100 glass tubes per minute when operated on the principle of volumetric piston-pumps / peristaltic pump type filling. Apart from that, this filling machine has a sleep tray available that offers a proper division of filled and sealed glass tubes or crushable ampoules.
Biological Indicator Filler Sealer Machine
In this biological indicator filling machine, Oxygen & LPG are the required gases for the purpose of filling and sealing tubes. This first-class ost filler sealer machine offers the maximum flexibility needed during the production of glass tubes accommodating veterinary medicines, agro-insecticides, and various other chemicals. Complete range including biological indicator filling machine, crushable ampoule filling machine, OST filling machine and various other such filler and sealer machines are available with Harsiddh that are suitable for all different kinds of glass tubes / ampoules.
Technical Specification
| Model No. | HFS-30 OST / HFS-55 OST / HFS-4 OST (Suitable For Onion Skin Tubes / Crushable Ampoules / Biological Indicator) |
| No. Of Head | One / Two / Four Heads |
| Size Of Onion Skin Tubes / Crushable Ampoules / Biological Indicators | Dia. 6mm to 15mm Length – 55mm to 100mm Or as per customer size |
| Filling Capacity | From 0.5ml to 5ml in single dose |
| Filling Type | Peristaltic Pumps Type Filling |
| Filling accuracy | +1% |
| Contact Parts | Stainless Steel AISI 316L (For Filling Nozzles) |
| Filling Head | One / Two / Four |
| Sealing Nozzle | One / Two / Four |
| Output / Minute | 10 to 100 Tubes / Minute (Depend on models) |
| Require Gases For Sealing | LPG & Oxygen (Mixture) |
| Nitrogen Purging | Available (Pre & Post) |
| Pre Heating | Available |
| Power Require | 0.5/1 H.P., 220 Volts, 1 Phase, 50 Hz OR Customized |
| Over All Dimensions | Depend on model |
| Net Weight | Depend on model |
| Gross Weight (With Wooden Case) | Depend on model |
Frequently Asked Questions
How does the machine ensure high-precision filling for such small volumes?
Since Biological Indicators require very specific amounts of growth media, the machine is equipped with a Micro-Dosing Filling System (typically using high-precision Peristaltic Pumps or Valveless Ceramic Pistons). This ensures a filling accuracy of ±0.5% to 1%, which is critical for the consistency of the chemical reaction and the reliability of the sterilization test results.
Can the machine handle the fragile glass ampoules used in Biological Indicators?
Yes. The Harsiddh BI machine is engineered with a Gentle "Pick and Place" or specialized Vibratory Feeding system specifically designed for glass ampoules. The transport star-wheels and placement heads are lined with soft, medical-grade materials to prevent any micro-cracks or breakage of the spore-bearing ampoule during the insertion process into the outer plastic vial.
What type of sealing technology is used for the BI vials?
Depending on the specific BI design, the machine utilizes either Ultrasonic Sealing or Induction Heat Sealing. These "non-contact" sealing methods are preferred because they create a robust, leak-proof weld between the cap and the vial without the risk of thermal degradation of the bacterial spores or the growth media inside.
What are the key compliance and cleanroom features of this machine?
As this machine is used in the production of medical validation tools, it is built to the highest cGMP and ISO standards:
Material: Entirely constructed of SS 316L for contact parts and SS 304 for the main frame.
Sterile Operation: Designed for integration under a Laminar Air Flow (LAF) hood to maintain an ISO Class 5 environment during the filling and sealing process.
Data Logging: Equipped with a PLC and HMI system that provides "Audit Trails" and batch reporting, essential for quality assurance in pharmaceutical manufacturing.
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